High production of interleukin‐10 and interferon‐γ in influenza‐associated MERS in the early phase
Identifieur interne : 002366 ( Main/Exploration ); précédent : 002365; suivant : 002367High production of interleukin‐10 and interferon‐γ in influenza‐associated MERS in the early phase
Auteurs : Shinichiro Morichi [Japon] ; Hisashi Kawashima [Japon] ; Hiroaki Ioi [Japon] ; Gaku Yamanaka [Japon] ; Yasuyo Kashiwagi [Japon] ; Akinori Hoshika [Japon]Source :
- Pediatrics International [ 1328-8067 ] ; 2012-08.
Descripteurs français
- KwdFr :
- MESH :
- biosynthèse : Interféron gamma, Interleukine-10.
- métabolisme : Encéphalite virale, Grippe humaine, Maladies de la rate.
- virologie : Maladies de la rate.
- Enfant, Facteurs temps, Grippe humaine, Humains, Mâle.
English descriptors
- KwdEn :
- MESH :
- chemical , biosynthesis : Interferon-gamma, Interleukin-10.
- complications : Influenza, Human.
- metabolism : Encephalitis, Viral, Influenza, Human, Splenic Diseases.
- virology : Splenic Diseases.
- Child, Humans, Male, Time Factors.
Abstract
Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) occurs in various diseases and pathologies, and the clinical symptoms are not consistent with the impaired region. The mechanism of the region specificity is unclear. We investigated the cytokine profiling in cerebrospinal fluid (CSF) and serum obtained from a child with MERS during influenza infection, and compared them with those of serious another serious type of influenza‐associated encephalopathy. There was no elevation of Interleukin (IL)‐1β, which induces convulsion. The inhibitory cytokines of IL‐10 and IFN‐γ were elevated in the early phase in CSF. Comparing them with other patients, the elevation of the cytokine levels were generally mild. Considering that the prognosis of this MERS case was favorable and high levels of inhibitory cytokines including IL‐10 and IFN‐γ might work to localize the lesion and to prevent sequelae.
Url:
DOI: 10.1111/j.1442-200X.2011.03483.x
Affiliations:
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to="538">538</biblScope><biblScope unit="page-count">3</biblScope><publisher>Blackwell Publishing Asia</publisher><pubPlace>Melbourne, Australia</pubPlace><date type="published" when="2012-08">2012-08</date></imprint><idno type="ISSN">1328-8067</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1328-8067</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Child</term><term>Encephalitis, Viral (metabolism)</term><term>Humans</term><term>Influenza, Human (complications)</term><term>Influenza, Human (metabolism)</term><term>Interferon-gamma (biosynthesis)</term><term>Interleukin-10 (biosynthesis)</term><term>Male</term><term>Splenic Diseases (metabolism)</term><term>Splenic Diseases (virology)</term><term>Time Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Encéphalite virale (métabolisme)</term><term>Enfant</term><term>Facteurs temps</term><term>Grippe humaine ()</term><term>Grippe humaine (métabolisme)</term><term>Humains</term><term>Interféron gamma (biosynthèse)</term><term>Interleukine-10 (biosynthèse)</term><term>Maladies de la rate (métabolisme)</term><term>Maladies de la rate (virologie)</term><term>Mâle</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Interferon-gamma</term><term>Interleukin-10</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Interféron gamma</term><term>Interleukine-10</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Encephalitis, Viral</term><term>Influenza, Human</term><term>Splenic Diseases</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Encéphalite virale</term><term>Grippe humaine</term><term>Maladies de la rate</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Maladies de la rate</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Splenic Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child</term><term>Humans</term><term>Male</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Enfant</term><term>Facteurs temps</term><term>Grippe humaine</term><term>Humains</term><term>Mâle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) occurs in various diseases and pathologies, and the clinical symptoms are not consistent with the impaired region. The mechanism of the region specificity is unclear. We investigated the cytokine profiling in cerebrospinal fluid (CSF) and serum obtained from a child with MERS during influenza infection, and compared them with those of serious another serious type of influenza‐associated encephalopathy. There was no elevation of Interleukin (IL)‐1β, which induces convulsion. The inhibitory cytokines of IL‐10 and IFN‐γ were elevated in the early phase in CSF. Comparing them with other patients, the elevation of the cytokine levels were generally mild. Considering that the prognosis of this MERS case was favorable and high levels of inhibitory cytokines including IL‐10 and IFN‐γ might work to localize the lesion and to prevent sequelae.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><region name="Région de Kantō"><name sortKey="Morichi, Shinichiro" sort="Morichi, Shinichiro" uniqKey="Morichi S" first="Shinichiro" last="Morichi">Shinichiro Morichi</name></region><name sortKey="Hoshika, Akinori" sort="Hoshika, Akinori" uniqKey="Hoshika A" first="Akinori" last="Hoshika">Akinori Hoshika</name><name sortKey="Ioi, Hiroaki" sort="Ioi, Hiroaki" uniqKey="Ioi H" first="Hiroaki" last="Ioi">Hiroaki Ioi</name><name sortKey="Kashiwagi, Yasuyo" sort="Kashiwagi, Yasuyo" uniqKey="Kashiwagi Y" first="Yasuyo" last="Kashiwagi">Yasuyo Kashiwagi</name><name sortKey="Kawashima, Hisashi" sort="Kawashima, Hisashi" uniqKey="Kawashima H" first="Hisashi" last="Kawashima">Hisashi Kawashima</name><name sortKey="Morichi, Shinichiro" sort="Morichi, Shinichiro" uniqKey="Morichi S" first="Shinichiro" last="Morichi">Shinichiro Morichi</name><name sortKey="Yamanaka, Gaku" sort="Yamanaka, Gaku" uniqKey="Yamanaka G" first="Gaku" last="Yamanaka">Gaku Yamanaka</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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